个人简介
尤朋涛：博士，硕士研究生导师，湖北中医药大学中药资源与中药化学湖北省重点实验室副主任。中华医学会中药药理分会委员，中国微循环学会转化医学专业委员会委员。主要研究方向为中药调节免疫、抗肿瘤及抗炎作用机理；获具有国际先进水平的科研成果2项；以项目骨干参与国家重点研发计划1项及多项国家自然基金面上项目研究工作；主持教育部博后基金1项，湖北省自然科学基金1项，教育厅青年项目1项；与多家企业及医院展开产学研合作，主持参与横向项目多项，以第一/通讯作者发表SCI论文20余篇。
主持或参加科研项目（课题）及人才计划项目情况：
1. 湖北省自然科学基金项目，复方参七散抗肿瘤药效物质和作用机制研究，5万元，结题，主持。
2. 湖北省教育厅科学研究计划项目，鹅不食草抗肿瘤活性成分Pe4诱导肿瘤细胞凋亡和自噬机制研究，2万元，结题，主持。
3. 博士后科学基金面上资助项目，基于凋亡和自噬的鞘蕊苏抗肿瘤活性成分抗肺癌机制研究，5万元，在研，主持。
4. 国家重点研发计划中医药现代化研究重点专项，子课题，茯苓物质基础研究升级及质量标准体系构建，180万元，在研，参加（第三）
5. 国家自然科学基金面上项目，基于液质联用技术与血小板活化通路探讨爵床抗血小板聚集的活性成分及其作用机理，63万元，在研，参与。
6. 湖北中医药大学青苗计划重点项目，基于基因芯片技术菝葜有效成分抗非小细胞肺癌的机制研究，5万元，结题，主持。
7. 国家自然科学基金面上项目，Anisomycin抑制T细胞的机制应用及靶点， 55万元，结题，参与。
8. 横向，愈肝龙抗肝纤维化作用机制研究，30万元，主持。
9. 横向，鳖甲抗纤维化活性成分分析及质量评价体系的建立，8万元，主持。
10.横向，护肝布祖热颗粒护肝作用机制及肾病药效研究，60万元，主持。
11.横向，显齿蛇葡萄药材及饮片质量标准研究，8万元，主持。
12.横向，当归饮子治疗慢性湿疹药效及作用机制研究，20万元，主持。
获得学术奖励
尤朋涛(7/16); 鞘蕊苏药材资源、物质基础及其产业化开发研究, 湖北省人民政府, 湖北省科技进步奖, 二等奖, 2019
近年以第一/通讯作者发表论文
(1) Lei Shi, Mengheng Wang, Haiping Li, Pengtao You*. MicroRNAs in Body Fluids: A More Promising Biomarker for Clear Cell Renal Cell Carcinoma. Cancer Management and Research. 2021(3) :7663-7675.
(2) Xinshuang Zou, Hailong Yin, Lei Shi, Haiping Li, Mengheng Wang, Wanci Song, Yang Luo, Weiliang Chen, Hezhen Wu, Yanfang Yang, Junfeng Zan, Yanwen Liu, Hanxiong Dan, Qiang Yin, Pengtao You*. Treatment with Gaoziban Tablet Ameliorates Depression by Promoting GSK-3βPhosphorylation to Enhance the Wnt/β-catenin Activation in the Hippocampus of Rats. Journal of Exploratory Research in Pharmacology. Published online: September 9, 2021
(2) Mengheng Wang, Hailong Yin, Yu Xia, Yijun Tu, Xinshuang Zou, Wanci Song, Laichun Luo, Hezhen Wu, Yanfang Yang, Junfeng Zan, Yanwen Liu, Hanxiong Dan, Qiang Yin, Pengtao You*. Huganbuzure Granule Attenuates Concanavalin-A-Induced Immune Liver Injury in Mice via Regulating the Balance of Th1/Th2/Th17/Treg Cells and Inhibiting Apoptosis. Evid Based Complement Alternat Med. 2021;2021:5578021.
(4) Hougang Li, Pengtao You*, Yu Xia, Yu Cai, Yijun Tu, Mengheng Wang, Wanci Song, Taimin Quan, Huiying Ren, Yanwen Liu, Hanxiong Dan, Shiqing Xu. Yu Gan Long Ameliorates Hepatic Fibrosis by Inhibiting PI3K/AKT, Ras/ERK and JAK1/STAT3 Signaling Pathways in CCl 4-induced Liver Fibrosis Rats. Curr Med Sci. 2020;40(3):539-547.
(5) Lu Shi, Yijun Tu, Siqi Ye, Yu Xia, Chaozhi Ma, Xiaozhi Peng, Yanwen Liu, Zhongzhu Ai, Pengtao You*. A Potential Anti-cancer Compound Separated from the Chloroform Extract of the Chinese Medicine Formula Shenqi San. Curr Med Sci. 2020;40(1):138-144.
(6) Xiaoqing Ma, Pengtao You*, Yan Xu, Xiaochuan Ye, Yijun Tu, Yanwen Liu, Min Yang, Dan Liu. Anti-Helicobacter pylori-associated gastritis effect of the ethyl acetate extract of Alpinia officinarum Hance through MAPK signaling pathway. J Ethnopharmacol. 2020;260:113100.
(7) Lu Shi, Yijun Tu, Yu Xia, Siqi Ye, Chaozhi Ma, Yanwen Liu, Pengtao You*. TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling Pathway. Anal Cell Pathol. 2019; 2019: 7697610. 20190430
(8) Xiaozhi Peng, Yijun Tu, San Fu, Yu Xia, Chaozhi Ma, Yanfang Yang, Hezhen Wu, Yanwen Liu, Pengtao You*. 14-Deoxycoleon U-induced endoplasmic reticulum stress-mediated apoptosis, autophagy, and cell cycle arrest in lung adenocarcinoma. Onco Targets Ther. 2019; 12: 5955–5965. 20190730
(9) Chaozhi Ma, Liyuan Zou, Yu Xia, Yijun Tu, Daquan Xue, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You*. Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix. J Cell Biochem. 2019; 120(6):9648-9655. 201906
(10) Dan Liu#, Pengtao You#, Yan Luo, Min Yang, Yanwen Liu, Galangin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Mitochondrial Pathway and Phosphatidylinositol 3-Kinase/Akt Inhibition, Pharmacology, 2018,102:58–66. (co-first authors)
(11) Yu Xia, Bo Yu, Chaozhi Ma, Yijun Tu, Ling Zhai, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan*, Pengtao You*, Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity, Biomed Pharmacother, 2018,106:1332–1338.
(12) Pengtao You#*, San Fu#, Kun Yu, Yu Xia, Hezhen Wu, Yanfang Yang, Chaozhi Ma, Dan Liu, Xin Chen, Jun Wang, Xiaochuan Ye, Yanwen Liu, Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-κB and p38/JNK pathway in LPS-induced BV-2 microglial cells, N-S Arch Pharmacol, 2018, 391:743–751.
(13) Wei Liu, Mengling Yang, Xuejian Chen, Li Li, Aijun Zhou, Shuhe Chen, Pengtao You*, Yanwen Liu*, Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction, Evid Based Complement Alternat Med, 2018, 2018: 5498698.
(14) Pengtao You#, Hezhen Wu#, Meng Deng, Jingling Peng, Fangping Li, Yanfang Yang*, Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation, Biomed Pharmacother, 2018, 98: 619-625.
(15) Yu Xia#, Lu Shi#, Zhongzhu Ai#, Dezhong Zhang, Yanwen Liu, Pengtao You*. Chinese Medicine Formula Shenqi San Extract Inhibits Proliferation of Human Lung Adenocarcinoma A549 Cells via Inducing Apoptosis. J Huazhong Univ Sci Technol [Med Sci]. 2017, 37(5): 766-771.
(16) Zuliang Hu#, Pengtao You#*, Sha Xiong#, Jianrong Gao, Yinping Tang, Xiaochuan Ye, Yu Xia, Dongquan Zhang, Yanwen Liu. Carapax Trionycis extracts inhibit fibrogenesis of activated hepatic stellate cells via TGF-β1/Smad and NFkB signaling. Biomed Pharmacother, 2017, 95: 11–17. (co-first authors and corresponding author)
(17) San Fu#, Yanfang Yang#, Dan Liu, Yan Luo, Xiaochuan Ye, Yanwen Liu, Xin Chen, Song Wang, Hezhen Wu, Yuhang Wang, Qiwei Hu, Pengtao You*. Flavonoids and tannins from Smilax china L. Rhizome induce apoptosis via mitochondrial pathway and MDM2-p53 signaling in human lung adenocarcinoma cells, Am J Chin Med, 2017, 45(2): 369-384.
(18) Bo Yu#, Pengtao You#, Meifang Song, Yang Zhou, Faquan Yu and Wenjie Zheng*. A facile and fast synthetic approach to create selenium nanoparticles with diverse shapes and their antioxidation ability, New J Chem, 2016, 40: 1118-1123. (co-first authors)
(19) Pengtao You, Haifeng Fu, Zhiwei Zhou, Yuan Wang, Manman Sun, Jing Liu*, Feiyue Xing*. Anisomycin represses in vitro and in vivo colon adenocarcinoma CT26 cell growthvia activation of caspase-cascade with reduction of carcino-embryonic antigen. Edorium Journal of Biomolecules, 2015, 1: 1-9.
(20) Pengtao You#, Feiyue Xing*, Chengquan Mao#, Zhencheng Chen#, Hui Zhang, Yifei Wang, Jun Xu, Jingfang Di, Shan Zeng, Jing Liu*. Jagged-1-Hes-1 signaling inhibits the differentiation of Th17 cells via RORγt. J Biol Regul Homeost Agents, 2013, 27(1): 79-93.
(21) Pengtao You#, Feiyue Xing*, Jie Huo#, Baoyu Wang, Jingfang Di, Shan Zeng, Jing Liu*. In vitro and in vivo evaluation of anisomycin against ehrlich ascites carcinoma, Oncol Rep, 2013, 29(6): 2227-2236.
(22) 熊莎，高建蓉，胡祖良，刘焱文，尤朋涛*. 鳖甲提取物对抑制TGF-β诱导的大鼠肝星状细胞活化的影响. 中国实验方剂学杂志, 2017, 23(19): 155-159.